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BNIP3 STEM CELL HAVING IMPROVED HYPOXIA ADAPTATION AND THERAPEUTIC POTENTIAL BY INDUCTION OF BNIP3 EXPRESSION AND METHOD FOR PREPARING THE SAME AND CELL THERAPEUTIC COMPOSITION COMPRISING THE SAME
BNIP3 STEM CELL HAVING IMPROVED HYPOXIA ADAPTATION AND THERAPEUTIC POTENTIAL BY INDUCTION OF BNIP3 EXPRESSION AND METHOD FOR PREPARING THE SAME AND CELL THERAPEUTIC COMPOSITION COMPRISING THE SAME
The present invention is a stem cell improved the ischemic adaptability and therapeutic function through the increased expression of BNIP3 (Bcl2 / adenovirus E1B 19kDa protein-interacting protein 3); Cell therapy composition for the prevention or treatment of lipid metabolism disease, containing the cells differentiated from the stem cells or the mesenchymal stem cells as an active ingredient; And increasing the expression of BNIP3, the present invention relates to a method for producing stem cells with improved therapeutic function in a hypoxic state. The present invention provides a method for removing BNIP3 to remove reactive oxygen species in mitochondria and to improve lipid metabolism. It is important that the mediation of the mitochondria mediated autophagy has been very important in enhancing the therapeutic function of stem cells. According to the present invention, the activation of reactive oxygen species through the regulation of BNIP3 activity in the hypoxic state By inhibiting accumulation and improving lipid metabolism, the efficiency can be significantly increased in the therapeutic application of mesenchymal stem cells, and can be widely used in various industrial fields such as medicine, pharmaceuticals, and veterinary medicine.
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