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SRM/MRM SRM/MRM ASSAYS FOR MOLECULAR PROFILING TUMOR TISSUE

机译:SRM / MRM SRM / MRM分子组织肿瘤检测

摘要

Provided herein is a method for developing a protein expression profile in a biological sample of formalin-immobilized culturing tissue obtained from a subject. The SRM/MRM assay provided herein detects proteins involved in cellular processes, including cell division, cell differentiation, cell growth inhibition, cellular metabolism, cell signaling, and tumor immune response/regulation directly in a subject's tumor tissue. And can be used to quantify. The SRM/MRM assay can provide a tumor tissue profile of the entire tissue microenvironment that indicates the optimal cancer therapy treatment for the subject, regardless of the cell origin of expression.
机译:本文提供了在从受试者获得的福尔马林固定的培养组织的生物学样品中建立蛋白质表达谱的方法。本文提供的SRM / MRM测定法直接在受试者的肿瘤组织中检测涉及细胞过程的蛋白质,包括细胞分裂,细胞分化,细胞生长抑制,细胞代谢,细胞信号传导和肿瘤免疫应答/调节。并且可以用来量化。 SRM / MRM分析可提供整个组织微环境的肿瘤组织概况,表明针对受试者的最佳癌症治疗方法,无论表达的细胞来源如何。

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