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New platform for co-stimulation, new CAR design and other enhancements for adoptive cell therapy
New platform for co-stimulation, new CAR design and other enhancements for adoptive cell therapy
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机译：共同刺激的新平台，新的CAR设计以及过继细胞疗法的其他增强功能
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摘要
The present disclosure provides compositions and methods that promote adoptive cell therapy. The present disclosure improves cell proliferation, expression and reduced apoptosis by including chimeric antigen receptor (CAR), synthetic immune receptor (SIR), etc. in combination with specific activators of NFkB activity, and in adoptive cell therapy. Provided are polynucleotides, vectors, systems and cells that improve cell persistence.
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