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DIPEPTIDE-BASED NEAR-INFRARED IMAGING PROBE FOR TARGETING HEPSIN, AND COMPOSITION FOR NEAR-INFRARED IMAGING FOR METASTATIC CANCER DIAGNOSIS AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METASTATIC CANCER, BOTH COMPOSITIONS COMPRISING PROBE
DIPEPTIDE-BASED NEAR-INFRARED IMAGING PROBE FOR TARGETING HEPSIN, AND COMPOSITION FOR NEAR-INFRARED IMAGING FOR METASTATIC CANCER DIAGNOSIS AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METASTATIC CANCER, BOTH COMPOSITIONS COMPRISING PROBE
The present invention relates to: a near-infrared imaging probe compound for targeting hepsin which is overexpressed in metastatic cancer; and a composition for near-infrared imaging for metastatic cancer diagnosis and a pharmaceutical composition for preventing and treating metastatic cancer, both compositions comprising the probe. According to the present invention, the compound is a fluorescent imaging probe comprising a fluorescent substance such as a BODIPY derivative and Sulfo-Cyanine7 and targeting hepsin, and has excellent hepsin inhibitory activity and is confirmed, by cell uptake results, to selectively bind to cells in which hepsin is expressed, thereby enabling the diagnosis, prevention, and treatment of carcinoma, such as prostate cancer, in which hepsin is overexpressed at an early stage, and being variously usable in the development of hepsin inhibitors for diagnosing carcinoma, such as prostate cancer.;COPYRIGHT KIPO 2020
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