首页> 外国专利> COMPOSITE POLYMER NANOFIBER MEMBRANE COLORIMETRIC SENSOR FOR DRUG INDICATION IN WHICH DRUG-DETECTING COLORIMETRIC DYE SUBSTANCE IS BOUND TO ONE-DIMENSIONAL NANOFIBER STRUCTURE

COMPOSITE POLYMER NANOFIBER MEMBRANE COLORIMETRIC SENSOR FOR DRUG INDICATION IN WHICH DRUG-DETECTING COLORIMETRIC DYE SUBSTANCE IS BOUND TO ONE-DIMENSIONAL NANOFIBER STRUCTURE

机译:用于检测毒品的比色染料物质的一维纳米纤维结构的复合聚合物纳米纤维膜比色传感器

摘要

Embodiments of the present invention relate to a composite polymer nanofiber membrane colorimetric sensor for drug indication in which a drug-detecting colorimetric dye substance, changed in the color by reacting to a specific drug, is uniformly bound to nanofibers, and a manufacturing method thereof. There are two specific methods for manufacturing the polymer nanofiber membrane colorimetric sensor to which the drug-detecting colorimetric dye substance is bound. A first method includes manufacturing an electrospinning solution by mixing the drug-detecting colorimetric dye substance with a polymer solution, and forming nanofibers to which the drug-detecting colorimetric dye substance is uniformly bound through electrospinning. A second method includes primarily synthesizing a polymer nanofiber membrane by electrospinning a pure polymer solution, and uniformly coating the polymer nanofiber membrane with the colorimetric dye substance by using various subsequent coating techniques. In this case, the reaction specific surface area is maximized as the drug-detecting colorimetric dye substance is uniformly bound to the inside and outside of the nanofibers. The manufacturing method can mass produce the nanofiber membrane colorimetric sensor by using relatively inexpensive electrospinning. Alternatively, a dye can be additionally and easily applied to the surface of the nanofiber membrane by using various coating techniques. Therefore, compared to a conventional drug-detecting colorimetric sensor, the composite polymer nanofiber membrane colorimetric sensor is expected to show effective colorimetric characteristics even with a small amount of a drug-detecting colorimetric dye. Through this high-performance drug-detecting colorimetric sensor, a colorimetric sensor array for various drugs (cocaine, morphine, LSD) can be produced and can be used as a drug early-diagnosis kit.;COPYRIGHT KIPO 2020
机译:本发明的实施方式涉及一种用于药物指示的复合聚合物纳米纤维膜比色传感器,其中通过与特定药物反应而颜色改变的药物检测比色染料物质均匀地结合至纳米纤维,及其制造方法。有两种特定的方法用于制造与药物检测比色染料物质结合的聚合物纳米纤维膜比色传感器。第一种方法包括通过将药物检测比色染料物质与聚合物溶液混合来制造静电纺丝溶液,并形成通过静电纺丝将药物检测比色染料物质均匀地结合到其上的纳米纤维。第二种方法包括主要通过静电纺丝纯聚合物溶液来合成聚合物纳米纤维膜,以及通过使用各种随后的涂覆技术用比色染料物质均匀地涂覆聚合物纳米纤维膜。在这种情况下,由于检测药物的比色染料物质均匀地结合到纳米纤维的内部和外部,因此反应比表面积最大化。该制造方法可以通过使用相对便宜的电纺丝来大量生产纳米纤维膜比色传感器。备选地,可以通过使用各种涂覆技术将染料另外且容易地施加至纳米纤维膜的表面。因此,与常规的药物检测比色传感器相比,预期复合聚合物纳米纤维膜比色传感器即使具有少量的药物检测比色染料也显示出有效的比色特性。通过这种高性能的药物检测比色传感器,可以生产出用于各种药物(可卡因,吗啡,LSD)的比色传感器阵列,并且可以用作药物早期诊断工具。; COPYRIGHT KIPO 2020

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