首页> 外国专利> A kit for detecting renal cell damage method for detecting renal tubular cell damage and method for screening a therapeutic agent for renal tubular cell damage

A kit for detecting renal cell damage method for detecting renal tubular cell damage and method for screening a therapeutic agent for renal tubular cell damage

机译:用于检测肾细胞损伤的试剂盒用于检测肾小管细胞损伤的方法和筛选用于肾小管细胞损伤的治疗剂的方法

摘要

The present invention relates to a kit for diagnosing cell damage in the glomerulus or renal tubules, and methods for providing information for diagnosing the same and screening a therapeutic substance for the same. As changes in the levels of Sirt1, HIF-1, CA9, and Bnip3 proteins are found in cell damage in the glomerulus or renal tubules, cell damage in the glomerulus or renal tubules caused by hypoxia or drugs can be diagnosed through changes in Sirt1, HIF-1, CA9, and Bnip3 proteins, which may be utilized in the development of cell-based specific diagnostic kits, diagnosis methods, methods for predicting and diagnosing cell damage induced by a drug on the glomerulus or renal tubules, and methods for screening candidate substances.
机译:本发明涉及用于诊断肾小球或肾小管中的细胞损伤的试剂盒,以及提供用于诊断肾小球或肾小管并为其筛选治疗物质的信息的方法。在肾小球或肾小管的细胞损伤中发现Sirt1,HIF-1,CA9和Bnip3蛋白水平的变化时,缺氧或药物引起的肾小球或肾小管的细胞损伤可通过Sirt1的变化来诊断, HIF-1,CA9和Bnip3蛋白,可用于开发基于细胞的特异性诊断试剂盒,诊断方法,预测和诊断药物在肾小球或肾小管上引起的细胞损伤的方法以及筛选方法候选物质。

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