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NANO-ANTIBIOTICS BASED ON SINGLE-CHAIN DEXTRAN NANOPARTICLES

机译：基于单链Dextran纳米粒子的纳米抗菌剂

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摘要

The present invention relates to a water-dispersible single-chain dextran methacrylate or acrylate based nanoconjugate, which comprises a water-dispersible single-chain dextran methacrylate or acrylate based nanoparticle and one or more hydrophilic active ingredients, and having: a particle size from 3 nm to 50 nm, a zeta potential from -25 mV to +20 mV, a percentage of intra-molecular crosslinking from 3% to 45% molar % of the total amount of monomer units present in the dextran methacrylate or acrylate chain, and a drug loading from 20% to 40% by weight of the drug in relation to the total weight of the nanoconjugate. It also relates to processes for their preparation, compositions containing them and their use in therapy.

机译：本发明涉及基于水分散性的甲基丙烯酸或丙烯酸单链葡聚糖的纳米共轭物，其包含基于水分散的甲基丙烯酸或丙烯酸酯的单链纳米粒子和一种或多种亲水性活性成分，并且具有：粒度为3分子量介于50纳米至50纳米之间，ζ电位介于-25 mV至+20 mV之间，分子内交联的百分比为甲基丙烯酸右旋糖酐或丙烯酸酯链中单体单元总量的3％至45％摩尔％，相对于纳米缀合物的总重量，药物载量为药物重量的20％至40％。它还涉及其制备方法，包含它们的组合物及其在治疗中的用途。

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公开/公告号WO2020212545A1

专利类型
公开/公告日2020-10-22

原文格式PDF
申请/专利权人 FUNDACIÓN CIDETEC;
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申请/专利号WO2020EP60804
发明设计人 GRACIA ESPAÑA RAQUEL;MOVELLAN JULIE;MARRADI MARCO;DUPIN DAMIEN;LOINAZ BORDONABE IRAIDA;MURGIA ESTEVE XABIER;
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申请日2020-04-17
分类号A61K47/69;A61K47/61;A61P31/04;
国家 WO
入库时间 2022-08-21 11:08:55

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