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THERAPEUTIC AND/OR PROPHYLACTIC AGENT FOR OLFACTORY DISORDERS AND NEURODEGENERATIVE DISEASES

机译：嗅觉障碍和神经退行性疾病的治疗和/或预防剂

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摘要

Provided are a therapeutic and/or prophylactic agent and nasal spray useful for therapy and prevention of olfactory disorders. The therapeutic and/or prophylactic agent according to the present invention contains at least a ganglioside GM1 derivative, and is used for therapy and/or prevention of olfactory disorders (e.g., olfactory disorders associated with neurodegenerative diseases). The ganglioside GM1 derivative can, for example, be represented by formula (1). (In the formula, R¹ represents a hydrogen atom or a C_1-4 alkyl group, R² represents a C_1-4 alkyl group, a phenyl group, or a phenyl-C_1-3 alkyl group, R³ represents a hydrogen atom or an acetyl group, R⁴ represents a hydroxyl group or a C_1-4 acylamino group, X represents an oxygen atom or a sulfur atom, and the dashed line portion of the steroid backbone represents a single bond or double bond.)

机译：提供了用于治疗和预防嗅觉障碍的治疗和/或预防剂和鼻喷雾剂。根据本发明的治疗剂和/或预防剂至少包含神经节苷脂GM1衍生物，并且用于治疗和/或预防嗅觉障碍（例如，与神经退行性疾病相关的嗅觉障碍）。神经节苷脂GM1衍生物可以例如由式（1）表示。（式中，R ^{1 代表氢原子或C _{1-4 烷基，R ^{2 代表C _{1 -4 烷基，苯基或苯基-C _{1-3 烷基，R ^{3 表示氢原子或乙酰基，R ^{4 表示羟基或C _{1-4 酰氨基，X表示氧原子或硫原子，类固醇骨架的虚线部分表示一个键或双键。）}}}}}}}}

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公开/公告号WO2020196694A1

专利类型
公开/公告日2020-10-01

原文格式PDF
申请/专利权人 CEOLIA PHARMA CO. LTD.;
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申请/专利号WO2020JP13503
发明设计人 NAGATANI TADASHI;YUASA FUTO;
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申请日2020-03-26
分类号A61P25;A61P25/16;A61P25/28;A61P27;A61K31/7028;
国家 WO
入库时间 2022-08-21 11:09:13

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