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ANTIBODY CAPABLE OF BINDING TO TRUNCATED MUTANT CALRETICULIN, AND DIAGNOSTIC, PROPHYLACTIC OR THERAPEUTIC DRUG FOR MYELOPROLIFERATIVE NEOPLASMS
ANTIBODY CAPABLE OF BINDING TO TRUNCATED MUTANT CALRETICULIN, AND DIAGNOSTIC, PROPHYLACTIC OR THERAPEUTIC DRUG FOR MYELOPROLIFERATIVE NEOPLASMS
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机译：能够与截短的突变钙网蛋白结合的抗体，以及用于骨髓增生性恶性肿瘤的诊断，预防或治疗药物
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摘要
Provided is a diagnostic, prophylactic or therapeutic drug for myeloproliferative neoplasms. An antibody which can bind to a truncated mutant CALR protein and has an antigen-recognition site in (a) a polypeptide chain comprising the amino acid sequence represented by SEQ ID NO: 1 or (b) a polypeptide chain comprising such an amino acid sequence that one amino acid residue or several amino acid residues are deleted, substituted or added in SEQ ID NO: 1, or a functional fragment of the antibody; and a diagnostic, prophylactic or therapeutic drug for myeloproliferative neoplasms, which comprises the antibody.
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机译：提供了用于骨髓增生性肿瘤的诊断，预防或治疗药物。可以结合截短的突变CALR蛋白并在（a）包含SEQ ID NO：1所示氨基酸序列的多肽链或（b）包含该氨基酸序列的多肽链中具有抗原识别位点的抗体在SEQ ID NO：1或抗体的功能片段中缺失，取代或添加一个氨基酸残基或几个氨基酸残基;以及用于骨髓增生性肿瘤的诊断，预防或治疗药物，其包含所述抗体。
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