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CONTRAST SOLUTION FOR THE CHARACTERISATION OF BIOLOGICAL SAMPLES BY ELECTRON OR CORRELATIVE MICROSCOPY

机译:电子或相关显微镜表征生物样品的对比方法

摘要

The invention relates to a solution comprising: a heteropolyacid and a lanthanide salt in a solvent consisting of a water/organic solvent mixture or an organic solvent. Optionally, the solution can also comprise an organic or inorganic buffer with a pH comprised in the interval of 4-6 or a strong base or acid. The object of the present invention also includes a use of said solution and any products of the reaction between the components thereof as a contrast medium for biological samples and a method for preparing biological samples that uses said solution in at least one step, for analysis by either correlative microscopy (CLEM) and electron microscopy (EM).
机译:本发明涉及一种溶液,该溶液在由水/有机溶剂混合物或有机溶剂组成的溶剂中包含:杂多酸和镧系元素盐。任选地,溶液还可以包含pH在4-6之间的有机或无机缓冲液或强碱或强酸。本发明的目的还包括所述溶液及其组分之间的反应的任何产物作为生物样品的造影剂的用途,以及在至少一个步骤中使用所述溶液的生物样品的制备方法,用于通过相关显微镜(CLEM)和电子显微镜(EM)。

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