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METHODS OF TREATMENT OF CANCER ASSOCIATED WITH CENTROSOME AMPLIFICATION

机译:中心体放大术治疗癌症的方法

摘要

This invention relates to the finding that centrosome amplification (CA) renders cancer cells more sensitive to certain anti-cancer compounds. The invention provides methods of treating cancer that displays centrosome amplification (CA) by administering a CA selective agent. Also provided are methods of screening for a CA selective agent comprising determining the effect of a test compound on the expression of a panel of CA associated genes in the cell and methods of determining the sensitivity of a cancer cell to a CA selective agent comprising determining the expression of a panel of CA associated genes in the cancer cell. Other aspects of the invention relate to measuring the expression of a panel of CA associated genes in order to assess a cancer condition in an individual or to assess genomic instability in a cancer cell.
机译:本发明涉及以下发现:中心体扩增(CA)使癌细胞对某些抗癌化合物更敏感。本发明提供了通过施用CA选择剂来治疗表现出中心体扩增(CA)的癌症的方法。还提供了筛选CA选择剂的方法,包括确定测试化合物对细胞中一系列CA相关基因的表达的影响,以及确定癌细胞对CA选择剂的敏感性的方法,包括确定癌细胞对CA选择剂的敏感性。一组CA相关基因在癌细胞中的表达。本发明的其他方面涉及测量一组CA相关基因的表达,以评估个体的癌症状况或评估癌细胞中的基因组不稳定性。

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