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NEW DIHYDROQUINAZOLINONES EXHIBITING PROTECTIVE ACTIVITY AGAINST INTRACELLULAR-ACTING TOXINS, INTRACELLULAR VIRUSES AND BACTERIA

机译:具有保护作用的新的双氢喹唑啉酮对胞内毒素,胞内病毒和细菌具有保护作用

摘要

The invention relates to a new family of compounds of the type 2,3-dihydroquinazolin-4(1H)-one and the use thereof as inhibitors of the toxic effects of intracellular-acting toxins, such as ricin, Shiga toxins or the cholera toxin, using retrograde transport to intoxicate the cells, or viruses or bacteria using retrograde and/or syntaxin 5-dependent transport to infect the cells, specifically viruses or bacteria entering into the cells by means of endocytosis, or intracellular parasites.
机译:本发明涉及新的2,3-二氢喹唑啉-4(1H)一型化合物家族及其在细胞内作用毒素如蓖麻毒蛋白,志贺氏菌毒素或霍乱毒素的毒性作用抑制剂中的用途。使用逆行转运来使细胞或病毒或细菌陶醉,使用逆行和/或语法5依赖转运来感染细胞,特别是通过内吞作用或进入细胞内的寄生虫进入细胞的病毒或细菌。

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