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METHOD FOR TREATMENT OF AUTISM SPECTRUM DISORDER, MOUSE FOR MONITORING AUTISM SPECTRUM DISORDER, AND METHOD FOR SCREENING CANDIDATE MATERIAL FOR PREVENTION OR TREATMENT OF AUTISM SPECTRUM DISORDER
METHOD FOR TREATMENT OF AUTISM SPECTRUM DISORDER, MOUSE FOR MONITORING AUTISM SPECTRUM DISORDER, AND METHOD FOR SCREENING CANDIDATE MATERIAL FOR PREVENTION OR TREATMENT OF AUTISM SPECTRUM DISORDER
The present invention relates to a method for treatment of autism spectrum disorder, a mouse for monitoring autism spectrum disorder, and a method for screening a candidate material for prevention or treatment of autism spectrum disorder. Specifically, after being introduced into neurons of the ventrolateral thalamus (VL), the laterodorsal thalamus (LD), or the striatum, halorhodopsin protein is induced to undergo hyperpolarization by exposure to light, thereby suppressing output signals (or collective excitement) of the ventrolateral thalamus (VL), the laterodorsal thalamus (LD), or the striatum neurons, with the resultant prophylactic or therapeutic effect on autism.
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