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METHODS FOR IDENTIFYING COMPOUNDS THAT INHIBIT REPAIR OF FRAME-SHIFT MUTATIONS BY MISMATCHED REPAIR SYSTEM
METHODS FOR IDENTIFYING COMPOUNDS THAT INHIBIT REPAIR OF FRAME-SHIFT MUTATIONS BY MISMATCHED REPAIR SYSTEM
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机译：识别通过错误修复系统来抑制框架移位突变的化合物的方法
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摘要
Disclosed herein is a method of treating a cancer in a subject that involves treating the subject with an agent that inhibits mismatch repair (MMR) in the cancer followed by treatment with a PD-1 or PDL-1 inhibitor to make the cancer hypersensitive to immune-surveillance. Also disclosed is a method for screening candidate agents to identify an MMR inhibitor that specifically inhibits the recognition/repair of frame-shift mutations by the MMR system.
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