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A RAPID, LOW-COST PROCESS FOR THE PREPARATION OF SERS SUBSTRATE AND SERS SUBSTRATE PREPARED THEREBY

机译:一种快速,低成本的制备SERS基质和由此制备的SERS基质的过程

摘要

The present invention relates to a cost effective and single step process for rapid manufacturing of paper-based SERS substrates (100), wherein chitosan is used for direct insitu reduction of the metallic precursor solutions for production of metallic nanoparticles on the substrates. The crucial step in the process involves the incubation of the paper-based substrates under humidifying conditions at an elevated temperature for a predetermined duration. The metal nanoparticles thus produced are homogenously deposited over the paper-based substrate making the paper-based substrate suitable for SERS analysis. The paper-based substrate thus developed is cost-effective, flexible, easy to load and is demonstrated to have exceptional sensitivity with detection limits of up to 1 pM.
机译:本发明涉及用于快速制造纸基SERS基底(100)的经济有效的单步方法,其中壳聚糖用于直接原位还原金属前体溶液以在基底上生产金属纳米颗粒。该过程中的关键步骤涉及将纸基基材在增湿条件下于升高的温度下孵育预定的时间。将由此产生的金属纳米颗粒均匀地沉积在纸基基材上,使得该纸基基材适合于SERS分析。如此开发的纸基基材具有成本效益,灵活,易于装载的特点,并具有卓越的灵敏度,检测极限高达1 pM。

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