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首页> 外国专利> Hydrogel based on silylated biomolecules for the cultivation of cardiomyocytes and stem cells, and use of the hydrogel thereof for the treatment of heart failure

Hydrogel based on silylated biomolecules for the cultivation of cardiomyocytes and stem cells, and use of the hydrogel thereof for the treatment of heart failure

机译：基于甲硅烷基化生物分子的水凝胶用于培养心肌细胞和干细胞，及其水凝胶在治疗心力衰竭中的用途

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摘要

An in vitro or ex vivo use of a hydrogel comprising one or more silylated biomolecules for the three-dimensional culture of cardiomyocytes or stem cells that are capable of differentiating into cardiomyocytes, wherein, when stem cells that are capable of differentiating into cardiomyocytes are mesenchymal stem cells obtained from adipose tissue, the hydrogel comprises agents that allow the induction of the differentiation of cardiomyocytes, and in which the hydrogel comprising silylated biomolecules is capable of forming a self-crosslinking hydrogel at a pH between 7.2 and 7, 6, in which said hydrogel contains 1 to 2% w / v Si-HPMC and has the following rheological characteristics at a pH value of 7.4 after 3 weeks of crosslinking: - a compression modulus at stress from 5% from 220 to 2600 Pa; - a storage module (G ') from 235 to 2500 Pa; - a loss modulus (G ") of 29 to 110 Pa, - a gel point of 5 to 45 minutes.
机译：包含一种或多种甲硅烷基化的生物分子的水凝胶在体外或离体用途中用于能够分化为心肌细胞的心肌细胞或干细胞的三维培养，其中，当能够分化为心肌细胞的干细胞为间充质干时从脂肪组织获得的细胞，水凝胶包含允许诱导心肌细胞分化的试剂，并且其中包含甲硅烷基化生物分子的水凝胶能够在7.2与7、6之间的pH值下形成自交联水凝胶，其中水凝胶含有1至2％w / v的Si-HPMC，在交联3周后，在pH值为7.4时具有以下流变特性：-5％的压缩模量为220至2600 Pa; -从235到2500 Pa的存储模块（G'）; -损失模量（G“）为29至110Pa，-胶凝点为5至45分钟。

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