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CHITOSAN- AND SILVER NANOPARTICLE-BASED BIO-NANOSTRUCTURES WITH APPLICATIONS IN PHARMACEUTICAL AND DERMATO-COSMETIC FIELD AND PROCESS FOR PREPARATION THEREOF
CHITOSAN- AND SILVER NANOPARTICLE-BASED BIO-NANOSTRUCTURES WITH APPLICATIONS IN PHARMACEUTICAL AND DERMATO-COSMETIC FIELD AND PROCESS FOR PREPARATION THEREOF
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机译：基于壳聚糖和银纳米颗粒的生物纳米结构及其在制药和皮肤美容领域的应用及其制备方法
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摘要
The invention relates to a process for preparing chitosan-based bio-nanostructures wherein silver nanoparticles and selective vegetal extracts are encapsulated, with applications in the pharmaceutical and dermato-cosmetic field. According to the invention, the process consists in combining a solution of chitosan : silver nanoparticles : vegetal extracts obtained from the rhizomes of the Cyperus rotundus L species, in an association ratio of 3 : 1 : 2 (v/v/v), homogenizing them by ultra-mixing for 2...5 min at a rate of 600...1000 rpm, adjusting the pH to 4.5...5.2, adding a solution of ionic cross-linking agents, such as sodium tripolyphosphate, followed by ionic gelation under magnetic stirring at 300 rpm, and followed by centrifugation at a rate of 8000 rpm, at the temperature of -10°C, for 15...20 min, to result in bio-nanostructures with sizes ranging between 193...198 nm, a nano-dispersion index of 0.315...0.433 and a ζ potential of 23...26 mV, with an encapsulation efficiency of 68...89%.
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