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GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) II MOLECULES
GENETICALLY MODIFIED MICE EXPRESSING CHIMERIC MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) II MOLECULES
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机译:基因表达修饰的小鼠嵌合主要组织相容性复合体(MHC)II分子
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摘要
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II ± and ² polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
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