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NON-HEMOLYTIC LLO FUSION PROTEINS AND USES THEREOF
NON-HEMOLYTIC LLO FUSION PROTEINS AND USES THEREOF
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机译:非溶血LLO融合蛋白及其用途
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摘要
A recombinant protein comprising a listeriolysin O (LLO) protein, wherein the LLO protein comprises a mutation, or deletion of 2-11 amino acid residues within the cholesterol-binding domain (CBD) of the LLO protein, and wherein the recombinant protein exhibits a greater than 100-fold reduction in hemolytic activity relative to wild-type LLO. The recombinant protein may further comprise a heterologous peptide, such as an antigenic peptide.
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