首页>
外国专利>
CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS.
CHIMERIC TRANSCRIPTION FACTOR VARIANTS WITH AUGMENTED SENSITIVITY TO DRUG LIGAND INDUCTION OF TRANSGENE EXPRESSION IN MAMMALIAN CELLS.
展开▼
机译:嵌合转录因子变体对哺乳动物细胞中转基因表达的药物配体诱导敏感性增强。
展开▼
页面导航
摘要
著录项
相似文献
摘要
Provided herein is a system for inducible expression of a chimeric antigen receptor in cells. The system comprises: a) a first nucleic acid comprising a first promoter inducible by a drug, wherein the first nucleic acid is operably linked to a first polynucleotide that encodes a chimeric antigen receptor, which comprises a ligand binding domain, a second polynucleotide, which encodes a spacer, a third polynucleotide, which encodes a transmembrane domain and a fourth polynucleotide, which encodes an intracellular signaling domain, and b) a second nucleic acid comprising a second promoter that is operably linked to a nucleic acid encoding a transcriptional activator for the first promoter inducible by drug. Methods of making such cells and methods of treatment using these cells are also provided.
展开▼