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Inhibition of bet protein by 2,3-benzodiazepine

机译：2,3-苯并二氮杂卓对赌注蛋白的抑制作用

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摘要

The invention relates to 2,3-benzodiazepine as the inhibiting protein of β protein, in particular the inhibiting protein of Brd4 inhibiting protein, and its general response formula ((I), wherein R1a, r1b, r1c, R2, R3, R4, R5, R5, R5, a and X have the meaning of the invention, and are used for preparing intermediate products of the compound of the invention, The pharmaceutical preparation containing the compound of the invention and its prevention and treatment use in hyperproliferative diseases, in particular tumor diseases. In addition, the invention relates to the application of bet protein inhibitor in benign hyperplasia.Atherosclerosis, septicaemia, autoimmune diseases, vascular diseases, viral infection, neurodegenerative diseases, inflammatory diseases, atherosclerotic diseases and male contraception.

机译：本发明涉及作为β蛋白的抑制蛋白，特别是Brd4抑制蛋白的抑制蛋白的2，3-苯并二氮杂and及其通式（（I），其中R1a，r1b，r1c，R2，R3，R4， R 5，R 5，R 5，a和X具有本发明的含义，并且用于制备本发明的化合物的中间产物。含有本发明的化合物的药物制剂及其在过度增生性疾病中的预防和治疗用途，另外，本发明涉及投注蛋白抑制剂在良性增生中的应用。动脉粥样硬化，败血病，自身免疫性疾病，血管疾病，病毒感染，神经退行性疾病，炎性疾病，动脉粥样硬化疾病和男性避孕。

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公开/公告号MA37854B1

专利类型
公开/公告日2020-01-31

原文格式PDF
申请/专利权人 BAYER PHARMA AKTIENGESELLSCHAFT;
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申请/专利号MA20130037854
发明设计人 BUSEMANN MATTHIAS;FERNANDEZ-MONTALVAN AMAURY ERNESTO;HOLTON SIMON;BÄURLE STEFAN;SCHMEES NORBERT;SIEGEL STEPHAN;CLEVE ARWED;HAENDLER BERNARD;MÖNNING URSULA;KRAUSE SABINE;LEJEUNE PASCALE;KUHNKE JOACHIM;
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申请日2013-08-13
分类号A61K31/55;A61P31/12;A61P35;C07D243/02;C07D401/04;C07D401/10;C07D401/12;C07D401/14;C07D403/10;C07D403/14;C07D409/10;C07D413/04;C07D413/10;C07D413/14;C07D417/10;
国家 MA
入库时间 2022-08-21 11:17:04

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