首页> 外国专利> Targeting trastuzumab-resistant her2 breast cancer with a her3-targeting nanoparticle

Targeting trastuzumab-resistant her2 breast cancer with a her3-targeting nanoparticle

机译：靶向Her3的纳米颗粒靶向抗曲妥珠单抗的her2乳腺癌

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摘要

Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2 therapy; and administering to the patient a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemical agent non-covalently linked to the nucleic acid sequence. Also disclosed are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with the drug delivery molecule. Further disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to anti-HER2 therapy; and administering to the patient a therapeutically effective amount of a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence. Finally disclosed herein are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence.

机译：本文公开了在患者中治疗癌症的方法，该方法包括鉴定对抗HER2疗法的治疗有抗性的患者。向患者施用药物递送分子，其包含适于靶向和/或穿透细胞类型的多肽分子;通过静电相互作用与多肽序列结合的核酸分子;以及与核酸序列非共价连接的化学试剂。还公开了在抗HER2治疗抗性HER2 +乳腺癌细胞中诱导凋亡的方法，该方法包括使抗HER2治疗抗性HER2 +乳腺癌细胞与药物递送分子接触。本文进一步公开了治疗患者癌症的方法，该方法包括鉴定对抗HER2疗法有抗性的患者。向患者施用治疗有效量的药物递送分子，其包含适于靶向和/或穿透细胞类型的多肽分子;结合于该多肽序列的磺化的Corrole分子。本文最后公开了在抗HER2疗法抗性HER2 +乳腺癌细胞中诱导凋亡的方法，该方法包括使抗HER2疗法抗药性HER2 +乳腺癌细胞与药物递送分子接触，所述药物递送分子包含适于靶向和/或靶向的多肽分子。穿透一种细胞结合于该多肽序列的磺化的Corrole分子。

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公开/公告号IL248046A

专利类型
公开/公告日2020-07-30

原文格式PDF
申请/专利权人 CEDARS-SINAI MEDICAL CENTER;MEDINA-KAUWE LALI K.;SIMS JESSICA;TAGUAIM MICHAEL;HANSON CHRIS;CUI XIAOJIANG;
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申请/专利号IL20160248046
发明设计人 MEDINA-KAUWE LALI K.;SIMS JESSICA;TAGUAIM MICHAEL;HANSON CHRIS;CUI XIAOJIANG;MEDINA-KAUWE LALI K.;SIMS JESSICA;TAGUAIM MICHAEL;HANSON CHRIS;CUI XIAOJIANG;
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申请日2016-09-26
分类号A61K31/517;A61K31/704;A61K31/711;A61K31/713;A61K38;A61K38/18;A61K39;A61K39/395;A61K47/62;A61K47/68;A61K48;A61P15;A61P35;C07K14/475;C12N15/87;
国家 IL
入库时间 2022-08-21 11:17:18

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