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METHOD FOR TREATING A BLOOD CLOTTING DISORDER AND METHOD FOR TREATING A BLEEDING EPISODE IN A MAMMAL
METHOD FOR TREATING A BLOOD CLOTTING DISORDER AND METHOD FOR TREATING A BLEEDING EPISODE IN A MAMMAL
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机译：治疗哺乳动物血液凝集异常的方法和出血点的方法
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摘要
The present invention relates to a method for treating a blood clotting disorder in a mammal, the method comprising subcutaneously administering a therapeutically effective amount of a composition comprising ADAMTS13 proteins, wherein the therapeutically effective amount of the ADAMTS13 is from 20 to 4,000 activity units per kilogram body weight, wherein the bioavailability of the ADAMTS13 after subcutaneous administration is 50-80% as compared to intravenous administration normalized for the same dose. Furthermore, the invention relates to a method for treating a bleeding episode in a mammal, the method comprising subcutaneously administering a therapeutically effective amount of a composition comprising ADAMTS13 proteins, wherein the therapeutically effective amount of the ADAMTS13 comprises at least 120-300% of the amount of a standard intravenous dose for treating a bleeding episode as measured in activity units per kilogram body weight, wherein the bioavailability of the ADAMTS13 after subcutaneous administration is 50-80% as compared to intravenous administration normalized for the same dose. Thus, the technical result of the invention consists in the unexpectedly high bioavailability of ADAMTS13 after subcutaneous administration.
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