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Pint-knockout mice with a premature, age-associated phenotype
Pint-knockout mice with a premature, age-associated phenotype
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机译:具有与年龄相关的表型过早的品脱基因敲除小鼠
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摘要
Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
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