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Pint-knockout mice with a premature, age-associated phenotype

机译:具有与年龄相关的表型过早的品脱基因敲除小鼠

摘要

Genetically modified non-human animals are provided that exhibit a functional lack of one or more IncRNAs. Methods and compositions for disrupting, deleting, and/or replacing IncRNA-encoding sequences are provided. Genetically modified mice that age prematurely are provided. Also provided are cells, tissues and embryos that are genetically modified to comprise a loss-of-function of one or more IncRNAs.
机译:提供了显示功能上缺乏一种或多种IncRNA的转基因非人类动物。提供了用于破坏,删除和/或替换IncRNA编码序列的方法和组合物。提供过早老化的转基因小鼠。还提供了经基因修饰以包含一种或多种IncRNA的功能丧失的细胞,组织和胚胎。

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