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METHODS OF PREPARATION FOR THE CONTROL OF QUALITY IN C-TAL LUXENE, FRANCE AND SIALIC ACID IN CONNECTED PRODUCTS

机译：连接产品中C-TAL，法国和唾液酸质量控制的制备方法

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摘要

A method for producing an antibody is currently provided,as an anti-TNF antibody (e.g.Infliximab) having a C-final lysine content of approximately 20% to 70%,and a salinic acid content of approximately 1% to 20%,which includes the cultivation of a zinc-responsive host cell contaminated with DNA coding the antibody to aa growing medium containing at least 0,5M zinc and control of zinc concentration in the growing medium;and thus producing the antibody.

机译：当前提供了一种产生抗体的方法，作为抗-TNF抗体（例如，英夫利昔单抗），其C-末端赖氨酸含量约为20％至70％，而其次生盐酸含量约为1％至20％，包括将被编码抗体的DNA污染的锌反应性宿主细胞培养到含有至少0.5M锌的生长培养基中，并控制生长培养基中锌的浓度;从而产生抗体。

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公开/公告号CY1120980T1

专利类型
公开/公告日2019-12-11

原文格式PDF
申请/专利权人 JANSSEN BIOTECH INC.;
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申请/专利号CY20181101150T
发明设计人 FLIKWEERT MARCEL;GOOCHEE CHARLES;MASLANKA FRANCIS;NAGEL FRANCISUS JOHANNES IGNATIUS;RYLAND JAMES;SCHAFER EUGENE;
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申请日2018-11-02
分类号C12N15/13;C07K16;C07K16/24;
国家 CY
入库时间 2022-08-21 11:17:57

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