首页> 外国专利> antibody against human cd147, antibody antigen binding fragment, pharmaceutical composition, use of the antibody or antigen binding fragment, polynucleotide, expression vector, host cell, method for producing the antibody or antigen binding fragment thereof , to predict the responsiveness to cancer treatment and to select subjects for cancer treatment, kit to determine responsiveness to cancer treatment, antibody-drug complex, and bispecific antibody

antibody against human cd147, antibody antigen binding fragment, pharmaceutical composition, use of the antibody or antigen binding fragment, polynucleotide, expression vector, host cell, method for producing the antibody or antigen binding fragment thereof , to predict the responsiveness to cancer treatment and to select subjects for cancer treatment, kit to determine responsiveness to cancer treatment, antibody-drug complex, and bispecific antibody

机译：抗人cd147抗体，抗体抗原结合片段，药物组合物，抗体或抗原结合片段的用途，多核苷酸，表达载体，宿主细胞，抗体或其抗原结合片段的生产方法，以预测对癌症治疗的反应性以及选择用于癌症治疗的受试者，用于确定对癌症治疗的反应性的试剂盒，抗体-药物复合物和双特异性抗体

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摘要

the present invention addresses the problem of providing a new anti-cd147 antibody having exceptional antitumor activity and exceptional safety. the present invention also addresses the problem of providing a remedy containing such an antibody. the present invention also addresses the problem of providing, inter alia, a method for treating tumors in which the antibody or drug is used. the present invention provides a cd147 specific antibody that activates cd147 and demonstrates a strong anti-tumor effect. the present invention provides an anti-cd147 antibody that demonstrates a strong anti-tumor effect independent of the effector function. the present invention provides a pharmaceutical composition that contains such an anti-cd147 antibody. the present invention provides a method for treating tumors in which such an anti-cd147 antibody and / or pharmaceutical composition is used.

机译：本发明解决了提供具有优异的抗肿瘤活性和优异的安全性的新型抗cd147抗体的问题。本发明还解决了提供包含这种抗体的药物的问题。本发明还解决了尤其提供使用抗体或药物治疗肿瘤的方法的问题。本发明提供了活化cd147并显示出强抗肿瘤作用的cd147特异性抗体。本发明提供了一种抗-cd147抗体，其显示了与效应子功能无关的强抗肿瘤作用。本发明提供了包含这种抗cd147抗体的药物组合物。本发明提供了一种治疗肿瘤的方法，其中使用了这种抗-cd147抗体和/或药物组合物。

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公开/公告号BR112020001657A2

专利类型
公开/公告日2020-07-21

原文格式PDF
申请/专利权人 DAIICHI SANKYO COMPANY LIMITED;
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申请/专利号BR20201101657
发明设计人 KAYOKO NANAI;KEISUKE FUKUCHI;KOZO YONEDA;MASATO AMANO;SHOJI YAMAMOTO;YUSUKE TOTOKI;
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申请日2018-07-26
分类号A61K39/395;A61P35;C07K16/30;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/08;
国家 BR
入库时间 2022-08-21 11:18:19

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