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首页> 外国专利> methylation classifier for the detection of invasive hpv-induced cancers, non-hpv-induced gynecological and anogenital cancers and their high-grade precursor lesions

methylation classifier for the detection of invasive hpv-induced cancers, non-hpv-induced gynecological and anogenital cancers and their high-grade precursor lesions

机译：甲基化分类器，用于检测浸润性hpv诱发的癌症，非hpv诱发的妇科和生殖器癌症及其高级前体病变

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摘要

the invention relates to the method for detecting high-grade precancerous lesions induced by hpv, invasive cancers induced by hpv and non-hpv-induced gynecological and anogenital cancers, said method comprises the detection of a methylation classifier consisting of the lhx8 genes, ascl1 and st6galnac5 and their regulation sequence in a cell, whereby hypermethylation indicates the presence of precursor lesions induced by hpv with invasive potential, invasive cancers induced by hpv and gynecological and anogenital cancers not induced by hpv. the invention further comprises the use of the methylation classifier consisting of the lhx8, ascl1 and st6galnac5 genes and their regulation sequences in such a method, and in a test kit to detect the methylation of lhx8, ascl1 and / or st6galnac5.
机译：本发明涉及检测由hpv引起的高级癌前病变，由hpv引起的浸润性癌和非hpv引起的妇科和生殖器癌的方法，所述方法包括检测由lhx8基因ascl1和st6galnac5及其在细胞中的调控序列，其中高甲基化表明存在由hpv诱导的具有浸润潜能的前体病变，由hpv诱导的浸润性癌以及未由hpv诱导的妇科和生殖器癌。本发明进一步包括由lhx8，ascl1和st6galnac5基因及其调控序列组成的甲基化分类器在这种方法中以及在测试试剂盒中用于检测lhx8，ascl1和/或st6galnac5的甲基化的用途。

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