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Specific Bacterial Species and Metabolite That Improves Immune Checkpoint Inhibitor Therapy Efficacy

机译:改善免疫检查点抑制剂治疗功效的特定细菌种类和代谢产物

摘要

The present invention includes compositions and methods for increasing an efficacy of an immune checkpoint inhibitor comprising: identifying a human patient in need of treatment for a melanoma; providing the human patient with an effective amount of the immune checkpoint inhibitor; and providing the human patient with at least one of: a probiotic bacteria, a prebiotic agent, or a xenobiotic agent, in the amount is effective to increase the potency of the immune checkpoint inhibitor against the melanoma.
机译:本发明包括用于提高免疫检查点抑制剂功效的组合物和方法,其包括:鉴定需要治疗黑素瘤的人类患者;和为人类患者提供有效量的免疫检查点抑制剂;并向人类患者提供至少一种有效量的益生菌,益生元或异种生物剂,以提高针对黑素瘤的免疫检查点抑制剂的效力。

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