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BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS
BIOMARKER FOR MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS, AND METHOD USING SAID BIOMARKER TO DETECT MENTAL DISORDERS INCLUDING COGNITIVE DISORDERS
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机译：包括认知障碍的精神疾病的生物标记，以及使用所述生物标志物检测包括认知障碍的精神疾病的方法
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摘要
Methods are provided that detect cognitive impairment including mild cognitive impairment and Alzheimer disease by using a protein or its partial peptide that differs in presence or absence. Novel biomarkers are also provided for cognitive impairment and non-psychiatric disease, as well as methods for detecting cognitive impairment using such biomarkers. Specifically, a biomarker for diagnosis is provided that comprises a protein fragment or peptide of not less than 5 amino acid residues arising from at least one protein or peptide selected from the group of proteins consisting of an amino acid sequence expressed by SEQ ID NO: 1, 3, 6, 8, 10, 13, 15, 18, or 20 and selected from the group of partial peptide in these proteins consisting of an amino acid sequence expressed by SEQ ID NO: 2, 4, 5, 7, 9, 11, 12, 14, 16, 17, 19, or 21.
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机译：提供了通过使用存在或不存在的蛋白质或其部分肽来检测包括轻度认知障碍和阿尔茨海默氏病在内的认知障碍的方法。还提供了用于认知障碍和非精神疾病的新型生物标志物，以及使用此类生物标志物检测认知障碍的方法。具体地，提供了一种用于诊断的生物标志物，其包括由至少一种选自由SEQ ID NO：1所示的氨基酸序列组成的蛋白质组中的蛋白质或肽产生的具有不少于5个氨基酸残基的蛋白质片段或肽。 ，3、6、8、10、13、15、18或20，并选自由SEQ ID NO：2、4、5、7、9、9表示的氨基酸序列组成的这些蛋白质中的部分肽11、12、14、16、17、19或21。
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