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TRIBLOCK PEPTIDE AMPHIPHILES, MICELLES AND METHODS OF USE

机译:三联肽肽,胶束和使用方法

摘要

One aspect of the present invention is directed to triblock peptides comprising a lipid moiety, a peptide block and a zwittenon-like block. Another aspect of the invention is directed to pharmaceutical compositions comprising the triblock peptides of the present in invention arranged in micelles in a pharmaceutically acceptable carrier. In certain embodiments, the pharmaceutical compositions of the present invention are vaccine compositions, which may further comprise an adjuvant. Another aspect of the invention is directed to methods of using the triblock peptides and compositions of the invention to treat a disease or condition.
机译:本发明的一个方面涉及三嵌段肽,其包含脂质部分,肽嵌段和类wittenon样嵌段。本发明的另一个方面涉及药物组合物,其包含以胶束形式布置在药学上可接受的载体中的本发明的三嵌段肽。在某些实施方案中,本发明的药物组合物是疫苗组合物,其可以进一步包含佐剂。本发明的另一方面涉及使用本发明的三嵌段肽和组合物治疗疾病或病症的方法。

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