首页> 外国专利> TARGETING OF ANAPLASTIC LYMPHOMA KINASE IN SQUAMOUS CELL CARCINOMA

TARGETING OF ANAPLASTIC LYMPHOMA KINASE IN SQUAMOUS CELL CARCINOMA

机译:鳞状细胞癌中非淋巴淋巴激酶的定位

摘要

Methods for identifying patients with high risk (progression, invasion, metastasis) squamous cell carcinoma using methylation and/or expression assays are disclosed. Also provided are methods of treating such high risk cancers with ALK inhibitors combined with anti-EGFR based therapies, as the data show a correlation between ALK hypomethylation and EGFR activation.
机译:公开了使用甲基化和/或表达测定法鉴别高危(进展,浸润,转移)鳞状细胞癌患者的方法。还提供了用ALK抑制剂与基于抗EGFR的疗法相结合的方法来治疗此类高危癌症的方法,因为数据表明ALK低甲基化与EGFR激活之间存在相关性。

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