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TARGETED DELIVERY OF ACTIVE AGENTS USING THERMALLY STIMULATED LARGE INCREASE OF PERFUSION BY HIGH INTENSITY FOCUSED ULTRASOUND
TARGETED DELIVERY OF ACTIVE AGENTS USING THERMALLY STIMULATED LARGE INCREASE OF PERFUSION BY HIGH INTENSITY FOCUSED ULTRASOUND
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机译:高强度聚焦超声通过热刺激大幅度增加灌注来有针对性地输送活性药物
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摘要
In some embodiments, the present disclosure pertains to a method of delivery of an active agent to a target tissue, in a subject in need thereof comprising positioning a high intensity focused ultrasound transducer to enable delivery of ultrasound energy to the target tissue. Such a method comprises energizing the high intensity focused ultrasound transducer; imaging at least a portion of the target tissue; and discontinuing delivery of ultrasound energy. Further, such a method may comprise administering the active agent to the subject under the conditions of thermal stimulation. In another embodiment, the present disclosure relates to a method of treating a tumor in a subject in need thereof comprising administering a therapeutic agent to the subject and providing thermal stimulation to the tumor. In some embodiments, there is provided a method for increasing the efficacy of a therapeutic agent in a target tissue.
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