首页> 外国专利> PYRAZINO2,3-bPYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY

PYRAZINO2,3-bPYRAZINE mTOR KINASE INHIBITORS FOR ONCOLOGY INDICATIONS AND DISEASES ASSOCIATED WITH THE mTOR/PI3K/AKT PATHWAY

机译：吡嗪并[2,3-b]吡嗪mTOR激酶抑制剂用于与mTOR / PI3K / AKT途径相关的肿瘤适应症和疾病

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摘要

Provided herein are Heteroaryl Compounds having the following structure:; embedded image

wherein R¹-R⁴are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions, comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.

机译：本文提供具有以下结构的杂芳基化合物： “嵌入式图像”

其中R ^{1 -R ^{4 如本文所定义，组合物包含有效量的杂芳基化合物和治疗或预防癌症，炎性疾病，免疫学疾病，神经退行性疾病，糖尿病，肥胖症，神经疾病，与年龄有关的疾病或心血管疾病的方法，包括向有此需要的患者施用有效量的杂芳基化合物。 ListItem>}}

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公开/公告号US2020262840A1

专利类型
公开/公告日2020-08-20

原文格式PDF
申请/专利权人 SIGNAL PHARMACEUTICALS LLC;
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申请/专利号US202016865512
发明设计人 JAN ELSNER;ROY L. HARRIS;BRANDEN GINGSEE LEE;DEBORAH MORTENSEN;GARRICK K. PACKARD;PATRICK PAPA;JASON PARNES;SOPHIE PERRIN-NINKOVIC;JENNIFER RIGGS;JOHN SAPIENZA;GRAZIELLA I. SHEVLIN;LIDA TEHRANI;JINGJING ZHAO;
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申请日2020-05-04
分类号C07D487/04;C07D487/14;C07D487/10;C07D471/14;C07D471/04;C07D241/20;C07D498/14;
国家 US
入库时间 2022-08-21 11:25:12

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