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DEVICE FOR MONITORING THE SPATIAL AND TEMPORAL DYNAMICS OF THROMBIN

机译：凝血酶时空动态监测装置

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摘要

The device for monitoring the spatial and temporal dynamics of thrombin that includes a temperature-controlled sealed chamber with a transparent window and a light trap, said chamber being filled with a fluid medium and designed to be capable of accommodating a cuvette containing a test sample of blood plasma, and into which a coagulation activating insert is placed, the latter having a substance which initiates the coagulation process applied to the butt end thereof, at least one means of illumination of the sample designed to be capable of receiving the light scattering signal from the sample and at least one first means of irradiation designed to be capable of exciting the fluorescence signal of a special marker that forms in the sample during the cleavage of a fluorogenic substrate previously added to the sample by one of the proteolytic enzymes of the coagulation system, a means of optical photo/video registration of light scattering/irradiation from the sample, a means for adjustment of pressure in the temperature-controlled sealed chamber designed to be capable of maintaining a pressure inside the chamber exceeding the atmospheric one, at that the device includes at least one second means of irradiation of the sample designed to be capable of exciting a fluorescence signal of the said marker, at least one first means of irradiation that provides irradiation of the sample in a direction perpendicular to the cuvette plane, and at least one second means of irradiation that provides irradiation of the sample at an angle to the cuvette plane.
机译：用于监测凝血酶的时空动态的装置，其包括具有透明窗口和光阱的温度控制的密闭室，所述密闭室填充有流体介质，并且被设计为能够容纳包含如下样品的比色杯：血浆中，并放置有凝血激活插入物，后者具有引发施加到其对接端的凝血过程的物质，该样品的至少一种照明装置设计成能够接收来自以下部件的光散射信号样品和至少一种第一辐射方式，其设计旨在能够激发特定标记物的荧光信号，该特殊标记物是在先前通过凝血系统的蛋白水解酶之一添加到样品中的荧光底物裂解过程中在样品中形成的，用于对来自样品的光散射/辐射进行光学照相/录像配准的装置，用于调节的装置温度控制的密闭腔室中的压力设计成能够保持腔室内部的压力超过大气压，因为该装置包括至少一个第二秒照射样品的装置，该装置设计成能够激发荧光信号在所述标记物的至少一个中，至少一个第一照射装置在垂直于比色皿平面的方向上照射样品，而至少一个第二照射装置在垂直于比色皿平面的方向照射样品。

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