首页> 外国专利> TREATMENT OF TRIPLE NEGATIVE BREAST CANCER OR COLORECTAL CANCER WITH LIVER METASTASES WITH AN ANTI PD-L1 ANTIBODY AND AN ONCOLYTIC VIRUS

TREATMENT OF TRIPLE NEGATIVE BREAST CANCER OR COLORECTAL CANCER WITH LIVER METASTASES WITH AN ANTI PD-L1 ANTIBODY AND AN ONCOLYTIC VIRUS

机译:肝转移性抗PD-L1抗体和溶瘤病毒治疗三阴性乳腺癌或大肠癌

摘要

Provided herein are methods of treating a subject with triple negative breast cancer or colorectal cancer. In exemplary embodiments, the method comprises administering to the subject a combination of an oncolytic virus, such as talimogene laherparepvec, and an anti-PD-L1 antibody, such as atezolizumab. In exemplary aspects, the oncolytic virus is administered to the subject at an initial dose followed by a second dose, wherein the initial dose is lower than the second dose. In exemplary aspects, the oncolytic virus is intrahepatically administered to the subject.
机译:本文提供了治疗患有三阴性乳腺癌或结肠直肠癌的受试者的方法。在示例性的实施方案中,该方法包括向受试者施用溶瘤病毒(例如talimogene laherparepvec)和抗PD-L B1B抗体(例如atezolizumab)的组合。在示例性方面,溶瘤病毒以初始剂量随后是第二剂量的形式施用于受试者,其中初始剂量低于第二剂量。在示例性方面,溶瘤病毒经肝内施用给受试者。

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