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Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
Use of glucocorticoid receptor antagonists in combination with glucocorticoids to treat adrenal insufficiency
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机译：糖皮质激素受体拮抗剂与糖皮质激素联合用于治疗肾上腺功能不全的用途
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摘要
This invention provides for a method of treating secondary adrenal insufficiency by co-administrating therapeutically effective amounts of a glucocorticoid and a glucocorticoid receptor antagonist to the patient in need thereof. In some embodiments, the method includes the proviso that the patient not be otherwise in need of treatment with a glucocorticoid and a glucocorticoid receptor antagonist. The treatment method can increase the patient's morning or basal cortisol level to at least about 12 μg/dL or a standard control level, and in turn, expedite significantly the recovery of the HPA axis. The method provided herein can improve health outcomes and life-threatening complications associated with secondary adrenal insufficiency.
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