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Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides
Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides
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机译：金黄色葡萄球菌 5型和8型荚膜多糖的缀合
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摘要
The invention provides a process for preparing a conjugate of a S. aureus type 5 or type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerising the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidising the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidised saccharide residue; and (c) coupling the oxidised saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process.
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