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How to Providing Personalized Cancer Vaccines and Cancer Vaccines

机译:如何提供个性化的癌症疫苗和癌症疫苗

摘要

The present invention relates to a patient-specific tumor treatment targeting individual expression patterns of tumor antigens, in particular shared tumor antigens, and individual tumor mutations. In one aspect, the present invention relates to a method for preventing or treating cancer in a patient comprising the steps of: (i) inducing a first immune response against one or more tumor antigens in the patient, and (ii) inducing a second immune response against one or more tumor antigens in the patient wherein the second immune response is specific for cancer specific somatic mutations present in cancer cells of the patient.
机译:本发明涉及针对患者的特异性肿瘤治疗,其靶向肿瘤抗原,特别是共享的肿瘤抗原的个体表达模式,以及个体肿瘤突变。一方面,本发明涉及一种用于预防或治疗患者癌症的方法,该方法包括以下步骤:(i)在患者体内诱导针对一种或多种肿瘤抗原的第一免疫应答,和(ii)诱导第二免疫反应。对患者中一种或多种肿瘤抗原的免疫应答,其中第二种免疫应答对存在于患者癌细胞中的癌症特异性体细胞突变具有特异性。

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