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Compositions and methods for simultaneous analysis of single cell genome, transcriptome and proteome
Compositions and methods for simultaneous analysis of single cell genome, transcriptome and proteome
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机译：同时分析单细胞基因组，转录组和蛋白质组的组成和方法
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摘要
Compositions and methods for multiplex analysis of one or more intracellular targets in a single cell are disclosed. An exemplary composition of the present disclosure is a surface comprising a plurality of capture agents operably linked thereto, wherein each capture agent specifically binds to a distinct intracellular target and comprises a plurality of capture agents. Forming a repeating pattern with a surface; a substrate comprising a plurality of chambers, the substrate releasably coupled to the surface, wherein each chamber of the plurality of chambers comprises A coating composition comprising a cell lysis composition; and a linker composition comprising a functionalized component and an extension component, comprising a substrate comprising at least one repetition of a repeating pattern of a plurality of capture agents.
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