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SUPPRESSORS OF DENDRITIC CELL MATURATION AND MATURATION SUPPRESSING METHODS AND PHARMACEUTICAL COMPOSITIONS

机译：树突状细胞成熟抑制因子及成熟抑制方法和药物组合物

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摘要

To provide dendritic cell maturation suppressors capable of suppressing dendritic cell maturation, and maturation suppressing methods using the dendritic cell maturation suppressors, pharmaceutical compositions comprising the dendritic cell maturation suppressors as effective ingredients, methods for screening dendritic cell maturation suppressors, and methods for screening therapeutic ingredients for diseases mediated by dendritic cells.SOLUTION: A dendritic cell maturation suppressor of the invention suppresses the maturation of dendritic cells by inhibiting the binding of TARM1 protein and a collagen protein. For example, the dendritic cell maturation suppressor may be a molecule that suppresses binding between TARM1 protein and a collagen protein by binding to the collagen binding domain of TARM1 protein, or a molecule that suppresses binding between TARM1 protein and a collagen protein by binding to a collagen protein.SELECTED DRAWING: Figure 5A

机译：为了提供能够抑制树突状细胞成熟的树突状细胞成熟抑制剂以及使用该树突状细胞成熟抑制剂的成熟抑制方法，以树突状细胞成熟抑制剂为有效成分的药物组合物，树突状细胞成熟抑制剂的筛选方法以及治疗成分的筛选方法解决：本发明的树突状细胞成熟抑制剂通过抑制TARM1蛋白和胶原蛋白的结合来抑制树突状细胞的成熟。例如，树突状细胞成熟抑制剂可以是通过结合至TARM1蛋白的胶原结合域来抑制TARM1蛋白与胶原蛋白之间的结合的分子，也可以是通过与TARM1蛋白结合而抑制TARM1蛋白与胶原蛋白之间的结合的分子。胶原蛋白。选图：图5A

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公开/公告号JP2020063198A

专利类型
公开/公告日2020-04-23

原文格式PDF
申请/专利权人 TOKYO UNIV OF SCIENCE;
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申请/专利号JP20180194614
发明设计人 IWAKURA YOICHIRO;YABE RIKIO;
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申请日2018-10-15
分类号A61K39/395;A61P19/02;A61P29;A61P43;C12N5/0784;C07K16/28;C07K16/18;C07K14/705;C07K14/78;C07K19;C12Q1/02;G01N33/50;G01N33/15;
国家 JP
入库时间 2022-08-21 11:36:21

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