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A19-144, A2-73 and certain anticholinesterase inhibitors, compositions and methods for the treatment of anti-seizures
A19-144, A2-73 and certain anticholinesterase inhibitors, compositions and methods for the treatment of anti-seizures
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机译:A19-144,A2-73和某些抗胆碱酯酶抑制剂,组合物和治疗癫痫发作的方法
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摘要
PROBLEM TO BE SOLVED: To provide A19-144, A2-73 and a specific anticholinesterase inhibitor, composition and method for anti-seizure treatment. The present invention relates to a dosage form comprising a therapeutically effective amount of A19-144 or A2-73 and a therapeutically effective amount of at least one AED. The present invention further includes methods of treating a subject in need of such treatment, comprising the step of administering a therapeutically effective amount of A19-144 or A2-73 in combination with a therapeutically effective amount of AED. In some embodiments, the AED is donepezil, with respect to donepezil being about 0.5 mg to about 23 mg, particularly about 0.5 mg to less than about 5 mg, more specifically about 1 to about 3.5 mg. Due to the synergistic effect in combination with A19-144 or A2-73, doses less than 0.5 mg are effective. [Selection diagram] None
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