首页> 外国专利> METHODS OF BOOSTING THYMIC REGENERATION IN PATIENTS SUFFERING FROM A THYMIC INJURY BY USING RANKL

METHODS OF BOOSTING THYMIC REGENERATION IN PATIENTS SUFFERING FROM A THYMIC INJURY BY USING RANKL

机译：通过使用RANKL增强患有胸腺损伤的患者的胸腺再生的方法

页面导航

摘要
著录项
相似文献

摘要

Cytoablative treatments lead to severe damages on thymic epithelial cells (TECs), which result in delayed de novo thymopoïesis and a prolonged period of T-cell immunodeficiency. Understanding the mechanisms that govern thymic regeneration is of paramount interest for the recovery of a functional immune system notably after bone marrow transplantation (BMT). Here, the inventors show that administration of RANK ligand (RANKL) after total body irradiation and BMT boosts thymic regeneration. Notably, this treatment is also beneficial upon BMT in aged individuals. The inventors show that RANKL can improve thymopoiesis in aged individuals affected by thymic involution. Finally, the inventors show that RANK receptor is conserved in the human thymus. Accordingly, one aspect of the present invention relates to a method of boosting thymic regeneration in a patient suffering from a thymic injury comprising administering to the subject a therapeutically effective amount of a RANKL polypeptide.

机译：细胞消融治疗会导致对胸腺上皮细胞（TECs）的严重损害，从而导致新来的胸腺细胞生成延迟和T细胞免疫缺陷的延长。尤其是在骨髓移植（BMT）之后，了解控制胸腺再生的机制对于恢复功能性免疫系统至关重要。在此，发明人表明，在全身照射和BMT后施用RANK配体（RANKL）促进胸腺再生。值得注意的是，该治疗对老年个体的BMT也有益。发明人表明，RANKL可以改善受胸腺退化影响的老年个体的胸腺细胞生成。最后，发明人表明RANK受体在人胸腺中是保守的。因此，本发明的一个方面涉及一种在患有胸腺损伤的患者中增强胸腺再生的方法，该方法包括向受试者施用治疗有效量的RANKL多肽。

著录项

公开/公告号EP3585415A1

专利类型
公开/公告日2020-01-01

原文格式PDF
申请/专利权人 INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE);UNIVERSITÉ DAIX MARSEILLE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS);
展开▼

申请/专利号EP20180705958
发明设计人 IRLA MAGALI;LOPES NOELLA;
展开▼

申请日2018-02-26
分类号A61K38/16;A61K38/17;A61P37;
国家 EP
入库时间 2022-08-21 11:38:32

相似文献

专利
外文文献
中文文献