首页> 外国专利> GONADOTROPIN-RELEASING HORMONE ANTAGONIST DOSING REGIMENS FOR TREATING UTERINE FIBROIDS AND REDUCING MENSTRUAL BLOOD LOSS

GONADOTROPIN-RELEASING HORMONE ANTAGONIST DOSING REGIMENS FOR TREATING UTERINE FIBROIDS AND REDUCING MENSTRUAL BLOOD LOSS

机译:释放性腺激素的激素拮抗剂,可治疗子宫纤维瘤和减少经血损失

摘要

The invention provides compositions and methods for reducing the volume of menstrual blood loss in a patient, such as a human patient, for instance, that has uterine fibroids, by administration of a gonadotropin-releasing hormone (GnRH) antagonist. Suitable GnRH antagonists useful in conjunction with the compositions and methods described herein include thieno[3,4d]pyrimidine derivatives, such as 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxypheny I]-2,4-dioxo-1,2,3,4-tetrahydrothieno[3,4d]pyrimidine-5-carboxylic acid and the choline salt thereof.
机译:本发明提供了通过给予促性腺激素释放激素(GnRH)拮抗剂来减少例如患有子宫肌瘤的患者(例如人类患者)的经期失血量的组合物和方法。与本文所述的组合物和方法结合使用的合适的GnRH拮抗剂包括噻吩并[3,4d]嘧啶衍生物,例如3- [2-氟-5-(2,3-二氟-6-甲氧基苄氧基)-4-甲氧基苯基I ] -2,4-二氧-1,2,3,4-四氢噻吩并[3,4d]嘧啶-5-羧酸及其胆碱盐。

著录项

  • 公开/公告号EP3634419A1

    专利类型

  • 公开/公告日2020-04-15

    原文格式PDF

  • 申请/专利权人 OBSEVA S.A.;

    申请/专利号EP20180731976

  • 申请日2018-06-05

  • 分类号A61K31/519;A61P15;

  • 国家 EP

  • 入库时间 2022-08-21 11:40:25

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