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lipid-lowering agents

机译：降脂药

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摘要

A pharmaceutical composition based on vitamins for use in the therapeutic regulation of lipid metabolism, wherein the vitamins include at least folic acid, vitamin B6 and vitamin B12 or physiologically acceptable derivatives and / or salts thereof, characterized in that the daily dose of at least 0.2 mg folic acid or at least 4 mg of vitamin B6 or at least 8 μg of vitamin B12, and at most 1.2 mg of folic acid, and wherein the physiologically acceptable derivatives and / or salts include: amides and esters of folic acid, and acid and base addition salts and mixed forms of Folic acid according to formula Ib: wherein R 1 is hydrogen, methyl, -HC = O or -HC = NH and R 2 is hydrogen or -HC = O or R 1 and R 2 taken together form a methylene or methylene bridge; pyridoxals and pyridoxamines and esters of the pyridoxine, pyridoxal and pyridoxamine and their acid addition salts according to formula IIa: wherein R3 is CHOH, CHO or the like r CHNH and R4 is OH or OPOH; Aquocobalamin, hydroxocobalamin, nitrosocobalamin, methylcobalamin and adenosylcobalamin and their acid addition salts.

机译：用于治疗脂质代谢的基于维生素的药物组合物，其中所述维生素至少包括叶酸，维生素B6和维生素B12或其生理上可接受的衍生物和/或其盐，其特征在于日剂量至少为0.2毫克叶酸或至少4毫克维生素B6或至少8微克维生素B12，以及最多1.2毫克叶酸，其中生理上可接受的衍生物和/或盐包括：叶酸的酰胺和酯，以及以及根据式Ib的叶酸的碱加成盐和混合形式：其中R 1为氢，甲基，-HC = O或-HC = NH和R 2为氢或-HC = O或R 1和R 2一起形成亚甲基或亚甲基桥;根据式IIa的吡ido醛和吡ido胺以及吡ido醇，吡ido醛和吡x胺的酯以及它们的酸加成盐：其中R3是CHOH，CHO等，r CHNH和R4是OH或OPOH; Aquocobalamin，hydroxocobalamin，nitrosocobalamin，methylcobalamin和adenosylcobalamin及其酸加成盐。

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公开/公告号DE202017007052U9

专利类型
公开/公告日2019-09-26

原文格式PDF
申请/专利权人 BIOENERGY HEALTHCARE GMBH;
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申请/专利号DE20172007052U
发明设计人
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申请日2017-10-02
分类号A61K31/714;A61K31/519;A61K31/4415;A61K31/14;A61K31/593;A61K36/28;A61K31/455;A61K31/122;A61K31/205;A61K31/19;A61P3/06;A23L33/15;
国家 DE
入库时间 2022-08-21 11:44:20

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