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Optimized host / vector system for the generation of protective mono- and multivalent subunit vaccines based on the yeast Kluyveromyces lactis
Optimized host / vector system for the generation of protective mono- and multivalent subunit vaccines based on the yeast Kluyveromyces lactis
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机译:优化的宿主/载体系统,用于产生基于酵母克鲁维酵母的保护性单价和多价亚基疫苗
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摘要
The invention relates to recombinant Kluyveromyces lactis (K. lactis) yeasts which are capable of highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for the generation of a protective immune response against pathogens. In particular, the invention provides K. lactis strains for the targeted cloning of foreign antigen encoding nucleic acids into the yeast genome of the K. lactis strain, characterized in that the K. lactis strain is used alternatively or in addition to the KILAC4 locus at the KIURA3-20 locus ( KLLA0E22771g) and / or at the KIMET5-1 locus (KLLA0B03938g) has integrated expression cassettes for foreign antigens. The invention further relates to integrative expression vectors and methods for producing the K. lactis strains of the invention and their use as vaccines.
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