首页> 外国专利> METHOD FOR PREDICTING THE RISK OF THE UNFAVORABLE OUTCOME IN THE PATIENTS SUFFERING ISCHEMIC HEART DISEASE WITHIN THE YEAR FOLLOWING CORONARY ARTERIAL BYPASS

METHOD FOR PREDICTING THE RISK OF THE UNFAVORABLE OUTCOME IN THE PATIENTS SUFFERING ISCHEMIC HEART DISEASE WITHIN THE YEAR FOLLOWING CORONARY ARTERIAL BYPASS

机译:冠状动脉旁路移植术后一年内缺血性心脏病患者不良预后的风险预测方法

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to cardiology, and can be used for prediction of risk of unfavorable outcome in patients with ischemic heart disease within a year after coronary artery bypass. Patients with ischemic heart disease on the first day of admission to hospital, prior to coronary artery bypass grafting, by flow cytofluorometry, phenotyping TLR9 in peripheral blood monocytes, %, using monoclonal antibodies. A prognostic coefficient K is calculated by formula: K = exp (-11.7 + 0.15 * x)/(1 + exp (-11.7 + 0.15) * x)), where K is a prognostic coefficient reflecting a probability of developing a negative cardiovascular event, and x is a value of the initial expression of TLR9 by monocytes, %. Constant value 11.7 and coefficient 0.15 before variable x are obtained by logistic regression by experimental method. At value K ≥ 0.639 predict a high risk of developing a negative cardiovascular event in the year following coronary artery bypass grafting. If K 0.639, the risk of developing a negative cardiovascular event is low.;EFFECT: method provides predicting a risk of developing a negative cardiovascular event in patients with ischemic heart disease within the year following coronary artery bypass grafting due to patient's phenotyping TLR9 in peripheral blood monocytes using monoclonal antibodies and calculating prognostic coefficient by formula obtained by logistic regression method.;1 cl, 2 dwg, 2 ex
机译:技术领域本发明涉及医学,即心脏病学,可用于预测冠状动脉搭桥术后一年内缺血性心脏病患者不良预后的风险。住院的第一天,患有缺血性心脏病的患者,在冠状动脉搭桥术之前,通过流式细胞术,使用单克隆抗体对外周血单核细胞中的TLR9进行表型分析,%。通过以下公式计算预后系数K:K = exp(-11.7 + 0.15 * x)/(1 + exp(-11.7 + 0.15)* x)),其中K是反映发展为阴性心血管的可能性的预后系数事件,并且x是单核细胞TLR9初始表达的值,%。通过实验方法进行逻辑回归,得出变量x之前的常数11.7和系数0.15。当K≥0.639时,预示冠状动脉搭桥术后一年发生负性心血管事件的高风险。如果K <0.639,则发生负性心血管事件的风险较低。;效果:该方法可预测由于患者的表型TLR9而在冠状动脉搭桥术后一年内缺血性心脏病患者发生负性心血管事件的风险。用单克隆抗体测定外周血单核细胞,并通过logistic回归法计算出的预后系数。1cl,2 dwg,2 ex

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