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首页> 外国专利> PREDICTION OF PREECLAMPSIA BASED ON DETERMINING EXTRACELLULAR FETAL DNA IN MATERNAL BLOOD WHEN SCREENING THE FIRST TRIMESTER OF PREGNANCY

PREDICTION OF PREECLAMPSIA BASED ON DETERMINING EXTRACELLULAR FETAL DNA IN MATERNAL BLOOD WHEN SCREENING THE FIRST TRIMESTER OF PREGNANCY

机译：筛查妊娠第一个三孕期时，基于确定母血中细胞外胎儿DNA的青光眼的预测

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FIELD: medicine.;SUBSTANCE: invention refers to medicine, particularly to obstetrics, and can be used for prediction of preeclampsia by determining extracellular fetal DNA in maternal blood when screening the first trimester of pregnancy. That is ensured by sampling maternal blood at 11–14 weeks of gestation, determining the content of extracellular pDNA by detecting the hypermethylated portion of the RASSF1A gene, Dopplerometric blood flow analysis in the uterine arteries with determining the average pulsation index. Detection of risk of developing PE by presented model: p=1/(1+e-z), where p is the probability of developing PE, e is a mathematical constant equal to 2.72, z is determined from the binary logistic regression equation of the following form: z=0.143*y1+2.138*y2-7.335, where y1 – concentration of extracellular fetal DNA in 11–14 weeks (GE/ml), y2 – average pulsation index in uterine arteries in 11–14 weeks, with value of p≥0.51 has a high risk of developing preeclampsia.;EFFECT: invention enables prediction of preeclampsia with sensitivity of 90 % and specificity of 90,9 % in women in the first trimester of pregnancy.;1 cl, 3 dwg, 1 tbl
机译：技术领域本发明涉及药物，特别是涉及产科，并且可以在筛查妊娠的前三个月时通过确定母体血液中的胎儿细胞外DNA来预测先兆子痫。通过在妊娠11–14周时抽取孕妇血液，通过检测RASSF1A基因的高甲基化部分，确定子宫动脉的多普勒血流分析并确定平均搏动指数来确定细胞外pDNA含量，可以确保这一点。通过提出的模型检测出现PE的风险：p = 1 /（1 + e -z ），其中p是发生PE的概率，e是一个等于2.72的数学常数，确定z根据以下形式的二进制逻辑回归方程式：z = 0.143 * y 1 + 2.138 * y 2 -7.335，其中y 1 – 11–14周细胞外胎儿DNA浓度（GE / ml），y 2 – 11–14周子宫动脉平均搏动指数，p≥0.51的发生风险很高子痫前期;效果：本发明能够预测子痫前期，在妊娠前三个月的妇女中敏感性为90％，特异性为90,9％.1 cl，3 dwg，1 tbl

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