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首页> 外国专利> METHOD FOR DIAGNOSING THE STAGE OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B

METHOD FOR DIAGNOSING THE STAGE OF HEPATIC FIBROSIS IN PATIENTS WITH CHRONIC VIRAL HEPATITIS B

机译：诊断慢性乙型肝炎患者肝纤维化分期的方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine and can find application in diagnostics of stage of hepatic fibrosis in patients with chronic viral hepatitis B. According to the proposed method, peripheral blood lymphocytes by DNA comet method determine percentage of DNA damage, perform clinical and general therapeutic biochemical blood analysis, using the predictive mathematical model based on the analysis results of the patients with chronic viral hepatitis B, the logistic regression coefficients with regularization are found, by means of which the auxiliary values es1 and es2 by following formulas: es1 = exp(6.354–0.019 *⋅Age – 0.096 *⋅Leukocytes – 0.066 *⋅ESR – 0.770 *⋅% of DNA in tail of comet); es2 = exp(11.944–0.019 *⋅Age – 0.096 *⋅Leukocytes – 0.066 *⋅ESR – 0.770 *⋅% of DNA in tail of comet), where exp – exponential function; age – patient's age, years; ESR – erythrocyte sedimentation rate, mm/h; leukocytes – leukocyte content in patient's peripheral blood, 109/l; % of DNA in tail of comet – content of DNA in tail of comet lymphocyte, %. Probability values P for each stage of fibrosis are then calculated by formula; ; ; ;and determining a stage of hepatic fibrosis, which corresponds to maximum probability value.;EFFECT: method provides higher diagnostic reliability of the stage of hepatic fibrosis and is characterized by ease of technical implementation, as well as interpretation of the study results, low invasiveness and safety for patients, namely absence of contraindications and potential risk of developing complications.;1 cl, 3 tbl, 1 ex
机译：领域：药物：本发明是指药物，可以在慢性乙型肝炎病毒性肝炎患者的肝纤维化分期的诊断中应用。根据提出的方法，通过DNA彗星法测定外周血淋巴细胞DNA损伤的百分比，进行在临床和一般治疗性生化血液分析中，使用基于慢性乙型肝炎患者分析结果的预测数学模型，找到具有正则化的对数回归系数，并借助其辅助值e s1 和e s2 的公式如下：e s1 = exp（6.354–0.019 *⋅Age– 0.096 *⋅白细胞– 0.066 *⋅ESR– 0.770 *⋅％彗星尾巴中的DNA）; e s2 = exp（11.944–0.019 *⋅年龄– 0.096 *⋅白细胞– 0.066 *⋅ESR– 0.770 *⋅彗星尾巴中DNA的百分比），其中exp –指数函数;年龄–患者的年龄，岁数; ESR –红细胞沉降速率，mm / h;白细胞–患者外周血中白细胞的含量为10 9 / l;彗星尾巴中DNA的百分比–彗星淋巴细胞尾巴中DNA的含量，％。然后通过公式计算纤维化每个阶段的概率值P; ; ; 效果：该方法对肝纤维化的这一阶段具有更高的诊断可靠性，其特点是技术实施容易，并且对研究结果的解释，低侵入性和患者的安全性，即没有禁忌症和出现并发症的潜在风险。; 1 cl，3 tbl，1 ex

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