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METHOD OF CORRECTION OF PLACENTAL MICROCIRCULATION DISORDERS WITH ADMA-LIKE MODEL OF PREECLAMPSIA

机译:像质感的ADMA模型校正局部微循环障碍的方法

摘要

FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to experimental pharmacology, and can be used for correction of placental microcirculation disorders with ADMA-like model preeclampsia. Model is reproduced preeclampsia in Wistar rats for 7 days every day from 14 to 20 of pregnancy, intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg. Against the background of simulated pathology, intragasting is administered through a probe of trimetazidine daily single dose of 6 mg/kg from 14 to 20 days of pregnancy.;EFFECT: method provides pronounced correction of placental microcirculation disorders with ADMA-like model preeclampsia using trimetazidine in experiment as a result of pronounced anti-ischemic and antioxidant action of trimetazidine.;1 cl, 1 tbl, 1 ex
机译:技术领域本发明涉及医学,即实验药理学,可用于校正具有ADMA样先兆子痫的胎盘微循环障碍。 Wistar大鼠从妊娠14天到20天每天7天复制子痫前期,腹膜内引入L-硝基-精氨酸甲酯25 mg / kg。在模拟病理学的背景下,妊娠14至20天通过曲美他嗪每日单剂量6 mg / kg的探针进行气内灌胃;效果:该方法可通过曲美他嗪对ADMA样先兆子痫提供胎盘微循环障碍的明显矫正在实验中由于曲美他嗪具有明显的抗缺血和抗氧化作用。; 1 cl,1 tbl,1 ex

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