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METHOD FOR PREDICTION OF DISEASE OUTCOME IN PATIENTS WITH GASTRIC CANCER AFTER SURGICAL MANAGEMENT

机译：外科治疗后胃癌患者疾病预后的预测方法

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FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to oncology, and represents a method for prediction of the disease outcome in patients with gastric cancer after surgical treatment, involving the malignant dialdehyde and catalase activity determining in tumor tissue samples taken during the operation, characterized by that the ratio of the malondialdehyde level to the catalase activity is calculated, and if its value is 0.150±0.030 predicting the favorable outcome of the disease, namely the absence of recurrences and/or metastases in the observation period from 1 month to 1.5 years; and if ratio of malondialdehyde level to catalase activity is 0.380±0.123 the unfavorable outcome of the disease is predicted, namely the presence of recurrences and/or metastases in the observation period from 1 month to 1.5 years and a high probability of death of the patients; at values between the above intervals, the result is considered to be undefined.;EFFECT: invention provides objective prediction of disease outcome in patients with gastric cancer after surgical intervention regardless of morphological nature of tumor, sex and age of patients, and when establishing a high probability of the unfavorable outcome of the disease, to change the antitumour treatment approach.;1 cl, 1 tbl, 3 ex
机译：技术领域本发明涉及医学，即肿瘤学，并且代表一种用于预测手术治疗后的胃癌患者的疾病结果的方法，该方法涉及在手术期间采集的肿瘤组织样品中确定恶性二醛和过氧化氢酶活性。手术，其特征在于计算丙二醛水平与过氧化氢酶活性的比率，并且如果其值为0.150±0.030，则预示该疾病的有利结果，即从1个月的观察期中无复发和/或转移至1。5年;如果丙二醛水平与过氧化氢酶活性之比为0.380±0.123，则可预测该疾病的不利结果，即在1个月至1.5年的观察期内有复发和/或转移，患者死亡的可能性很高。 ;效果：本发明提供了手术干预后胃癌患者疾病预后的客观预测，而与肿瘤的形态学性质，患者的性别和年龄以及建立肿瘤的时间无关。疾病不利结果的可能性很高，因此改变了抗肿瘤治疗方法。; 1 cl，1 tbl，3 ex

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